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Because of its slow action and high post-treatment recurrence rate, ursodeoxycholic acid is not widely recommended, and its use is generally reserved for those who cannot undergo surgery (Portincasa 2012

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3.7 Structural insights into the mode of action of the thiol switch in GSAAT1 The X-ray structure of the Arabidopsis GSAAT1 dimer has been reported at 1.25 Å resolution ( At (PDB ID: 5hdm) revealed that Cys138, Cys168 and Cys190 are more buried within the dimeric structure, while Cys396 is exposed on the surface of GSAAT, albeit mirror symmetrically on opposite sides of the dimer ( Figure 7A )